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Between September 2010 and May 2014 the PARTNER study prospectively enrolled 1166 serodifferent couples at 75 clinical sites in 14 European countries.
Entry criteria included the positive partner having an undetectable viral load on ART and that the couples were not always using condoms when they had sex.
The PARTNER study provides more than three times the amount of follow-up time from people not using condoms than all the previous studies combined.
This includes 500 couple-years of follow up from people having anal sex without condoms.
This reverses the common assumption that, by definition, some level of risk always exists when one partner is HIV positive.
The PARTNER study provides good evidence that undetectable viral load might be a threshold below which sexual HIV transmission does not occur.
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